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Acute and developmental toxic effects of mono-halogenated and halomethyl naphthalenes on zebrafish (Danio rerio) embryos: Cardiac malformation after 2-bromomethyl naphthalene exposure
Highlights
• 2-Bromomethyl naphthalene (2-BMN) showed potent lethal effects to zebrafish embryos. • 2-BMN caused malformations in zebrafish embryos such as pericardial edemas. • 2-BMN induced abnormal heart formation in Tg(cmlc2:EGFP) with lower heart beat rate. • An arrythmia-related nppa gene during development was upregulated by 2-BMN treatment.
Jungeun Park
,
Yurim Kim
,
Hwang-Ju Jeon
,
Kyeongnam Kim
,
Chaeeun Kim
,
Seung ki Lee
,
Jino Son
,
Sung-Eun Lee
DOI
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