EPN

Acute toxicity of the insecticide EPN upon zebrafish (Danio rerio) embryos and its related adverse effects: Verification of abnormal cardiac development and seizure-like events
Highlights • EPN showed no changes in survival and hatching rates of zebrafish embryos. • In 250 ppb and 500 ppb levels, edemas were observed in heart and yolk sac. • Abnormal heart formation in Tg(cmlc2:EGFP) was clearly observed at 500 ppb level. • The slowed heartbeat confirmed using Tg(gata1:EGFP), showing stagnant blood flow. • Seizure-like events were determined using EEG system in EPN-treated larvae.
Hyeseung Choe, Myoung-Jin Kim, Hwang-Ju Jeon, Kyeongnam Kim, Chaeeun Kim, Jungeun Park, Junnyeong Shin, Sang-Ryong Lee, Sung-Eun Lee
DOI
Acute toxicity of the insecticide EPN upon zebrafish (Danio rerio) embryos and its related adverse effects: Verification of abnormal cardiac development and seizure-like events